ea0063oc7.2 | Endocrine Connections 1 | ECE2019
Bessiene Laura
, Hescot Segolene
, Bourdin-Pintueles Alexandra
, Dumeige Laurence
, Vitellius Geraldine
, Perrot Julie
, Xu Qiong-Yao
, Vu Thi-An
, Sachs Laurent
, Pussard Eric
, Lombes Marc
, Viengchareun Say
, Martinerie Laetitia
The 11-beta hydroxysteroid dehydrogenase (11βHSD) isozymes are well-known regulators of glucocorticoid hormone metabolism: 11βHSD2, mostly expressed in the distal nephron, converts cortisol [F] into cortisone [E] in humans or corticosterone into 11-dehydrocorticosterone in rodents (11-dehydro derivatives being inactive compounds), and 11βHSD1, ubiquitously expressed but predominantly in the liver, catalyzes the opposite reaction. Under pathophysiological conditi...